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HomeLab TestArthritisAnti Cyclic Citrullinated Peptide Antibody (CCP)

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Anti Cyclic Citrullinated Peptide Antibody (CCP)

  • You need to provide Blood
  • Overnight fasting is not mandatory
  • This test is for Male, Female


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What is Anti CCP?

This test looks for anti cyclic citrullinated peptide (CCP) antibodies in the blood, which are a type of autoantibodies that can cause disease by attacking the body’s healthy cells. If CCP antibodies are found in your blood, it can be a sign of rheumatoid arthritis (RA). This test is advised if you show symptoms of rheumatoid arthritis-like joint pain, low-grade fever, joint swelling, and fatigue.

CCP antibodies are found in more than 75% of people who have rheumatoid arthritis. As rheumatoid arthritis can be difficult to diagnose, especially in its early stages, other tests such as X-ray and C reactive protein tests are also recommended.


Why is Anti CCP done?
  • To diagnose rheumatoid arthritis
  • To differentiate rheumatoid arthritis from other arthritis
  • To evaluate the prognosis of the patient with rheumatoid arthritis


What does Anti CCP Measure?

Anti cyclic citrullinated peptide antibodies are autoantibodies which are produced by the immune system that attack against the cyclic citrullinated peptide. Due to these attacks, inflammatory symptoms are produced in the body which is most commonly seen in rheumatoid arthritis. The Anti CCP antibodies can be present in patients prior to the start of symptoms of rheumatoid arthritis. The presence of positive Anti CCP antibodies in rheumatoid arthritis patients is said to be due to the combination of genetics and environmental factors. These patients have a common sequence of amino acids which is called as shared epitope that is encoded in specific genetic markers called human leukocyte antigens (HLA) which are responsible for producing proteins to control immune responses. The shared epitope attaches to these proteins to produce Anti CCP antibodies.

Interpreting Anti CCP results



Anti CCP antibody test positivity indicates Rheumatoid Arthritis

Additional information


Healths First, Lal Pathlab, Medcis Pathlab


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